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The follicle effects described in the 2007 study (PMID 17703734) operate over the growth phase, which is far longer than four weeks, so visible density or thickness changes this early aren't predicted by the biology

In a 16-week study of nightly GHRH-(1-29) dosing in older adults, nocturnal growth-hormone output stayed elevated across the full treatment period and IGF-1 rose and remained above baseline, with no sign of the pituitary becoming desensitized to nightly stimulation over those 16 weeks (Khorram et al., 1997)

Each protocol is individualized based on clinical assessment, health history, and specific wellness goals

Endogenous MOTS-c levels decline as we age