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129 While the primary endpoints were not met, an unexpected finding emerged four weeks after treatment cessation: patients receiving 50 mg/day of nivalexanil exhibited significantly higher THI scores than placebo recipients, raising concerns about possible rebound effects or symptom exacerbation after withdrawal

Because the article uses it to ask whether semaglutide is a short-term intervention or a sustained treatment

By early 2025, Novo estimated roughly 30% of all semaglutide volume in the U.S

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