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Progress in stem cell research for liver therapy The first research on cell therapy dates back to 1976, when Najarian pioneered the transplantation of allogeneic hepatocytes into rats with congenital enzyme deficiency disease

Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)

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Finally, the samples were brought to dryness using an evaporation system (TurboVap LV, Biotage, Uppsala, Sweden) and resuspended in 100 L methanol-water (50/50, v/v) for UPLC-MS/MS automated injections