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Storage considerations: Hyaluronic acid is stable at room temp Copper peptide is the limiting factor Store based on copper peptide requirements Refrigeration benefits the copper peptide component Copper peptide + retinol combinations Some advanced formulations combine copper peptides with retinol

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Further, animal studies have shown that there is an increase in Nrf2 expression, increasing the expression of antioxidant enzymes after acute (Muthusamy et al., 2012) and chronic PE (Gounder et al., 2012)