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Klasen, Claudia Cavelti-Weder, and Tarik Delko have no conflicts of interest or financial ties to disclose

FIGURE 2 3.1 Activation of inflammation-related signaling pathways in skin diseases ROS are important regulators of inflammatory responses, capable of activating various inflammatory signaling pathways, promoting the secretion and release of inflammatory factors, and forming a chronic inflammatory microenvironment (Figure 3)

197 For instance, increased blood urea concentrations can alter the microbiome, resulting in the increased generation of toxic metabolites from the gastrointestinal tract as well as an increased tendency for toxins to cross the gut barrier, which can promote further kidney injury

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