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The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months

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QC methodology, step by step The standard QC chain for a sealed multi-dose pen follows this sequence: API identity by mass spectrometry HPLC assay against reference standard Endotoxin by LAL Sterility by membrane filtration Fill-volume verification Sealed-pack release The sealed pharmaceutical pack preserves cold-chain integrity by class-based expectation of 28 C pre-use storage, mirroring licensed semaglutide pen handling [5][6]