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The tissue responds to UV exposure, smoking, hormonal fluctuations, cosmetic irritation, or mechanical trauma by producing more pigment than it should

( 10.1002/14651858.CD007411.pub4) [DOI] [PMC free article] [PubMed] [Google Scholar] Steiber A, Kerner J, Hoppel CL.2004

Int J Mol Med

Some patients who discuss dose splitting with their provider include: Patients with nausea after injections Individuals sensitive to medications Patients struggling with appetite crashes People who feel the medication wears off too quickly Patients experiencing fatigue after injections Not every patient benefits from this approach