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To test whether the mean DNA methylation level at CYP2E1 was different between the two groups of acetaminophen detection, we fit linear regression models using R/Bioconductor package limma [32] for each of the 28 candidate CpG sites

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High-quality human clinical trials are lacking, and optimal dosing, long-term safety, and efficacy have not been established, meaning its use for IBS and Crohns should be considered investigational rather than a standard therapeutic option