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Amino acid imbalances, particularly in glutamate, methionine, glycine, and leucine, are frequently observed in GHD patients, contributing to muscle weakness, nitrogen imbalance, and metabolic inefficiencies (63, 64).Importantly, our study observed that biomarkers such as glycine, pyruvate, and leucine normalized following GH therapy, reflecting the well-documented metabolic effects of GH replacement in humans (20)

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Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

We determined the GTP-binding protein coupling of human GCGR expressed in HEK293T cells