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Some studies suggest it can influence the expression or signaling of Nerve Growth Factor (NGF) and Epidermal Growth Factor (EGF), contributing to its neuroprotective and wound-healing properties observed in preclinical research
While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization
Mood changes, including depression or irritability, can also be related to low B12 levels
Patients who are very lean in the abdominal area or who experience more discomfort there often find the thigh more comfortable
