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PubMed Aronne, L.J., Sattar, N., Horn, D.B., Bays, H.E., Wharton, S., Lin, W.Y., Ahmad, N.N., Zhang, S., Liao, R., Bunck, M.C., Jouravskaya, I., Hesse, D., Jastreboff, A.M., & SURMOUNT-1 Investigators

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Broad Melanocortin Activity: It activates multiple melanocortin receptors ( MC1R, MC3R, MC4R, MC5R ), which supports research across pigmentation, neuroendocrine, and metabolic signaling pathways

The recommended dose for weight loss is 0.25 to 0.5 mg occasionally up to 1-2 mg once weekly, with a maximum dose of 2 mg per week