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The 2.5 mg dose is intended only for treatment initiation to improve tolerability and is not a maintenance dose for chronic weight management

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Evidence from pivotal trials, such as the EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients-Removing Excess Glucose) and CANVAS (Canagliflozin Cardiovascular Assessment Study) studies, underscores the kidney benefits of SGLT2is, highlighting significant reductions in the progression of kidney disease and CV mortality[70,71]