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In this combined analysis, we observe that the degree of BMI loss depends strongly on sex, drug type, time on treatment and drug dosage, consistent with previous reports 11 , and has a relatively weak dependence on pre-treatment BMI (with higher starting BMI associated with greater BMI loss)
Though the number of samples, and thus principal components, for each tissue-type varied, similar patterns of explained variance are observed across tissue-types compared to the baseline components (Supp
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