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Mt s t bo thc bo c kh nng tit ra cc enzym gi l myeloperoxidase c th xc tc phn ng ca H2O2 v halogenua (clorua hoc bromua) to ra axit hypochlorous (HOCl) hoc axit hypobromous (HOBr) ( Bakkenist v cng s, 1980 )
no published inhibition or induction data Primary clinical concern / increased bleeding risk from additive vascular and hemostatic effects Severity estimate / moderate (theoretical), based on pharmacodynamic reasoning Monitoring needed / CBC with platelets, PT/INR, anti-Factor Xa levels, signs of bleeding Dose adjustment / no validated protocol exists
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