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Although 5% weight loss did not show a net benefit, Moll and colleagues noted that it could be net beneficial for some individuals, depending on their willingness to accept the harm outcomes. For example, one of the harm outcomes that highly influenced the unfavorable benefit-harm balance of tirzepatide was alopecia, they explained

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Murphy advised us to stick to off-label use of approved peptides, instead of prescribing their unapproved cousins