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KPV (Lys-Pro-Val) is a synthetic tripeptide representing the C-terminal sequence of alpha-melanocyte-stimulating hormone (-MSH)

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In osteoarthritis, oxidative stress causes excessive ROS in chondrocytes, disrupting the binding of Keap1 and Nrf2, allowing Nrf2 to enter the nucleus, activating the antioxidant response element (ARE), and increasing the expression of antioxidant proteins, such as HO-1 and NQO-1 [69], which can attenuate oxidative stress and inflammatory responses and protect chondrocytes