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10.1093/cvr/cvab243 73

Like semaglutide, it may remain active in the body for several weeks depending on: Dosage Frequency of use Metabolism Overall health Its extended duration is one reason tirzepatide is commonly administered weekly

To contextualize these percentages, a person weighing 250 pounds at baseline could expect to lose approximately 52 pounds on the 15 mg dose, 49 pounds on 10 mg, or 38 pounds on 5 mg over the study period

Nature 375 , 146148 (1995)