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Subsequently, secondary bile acids, key signaling molecules produced by bile acids and gut microbiota metabolism, are bound to membrane receptors (Takeda G protein-coupled receptor 5, TGR5/G protein-coupled bile acid receptor 1, GPBAR1) and nuclear receptors (Farnesoid X Receptor, FXR), which stimulates colonic secretion of GLP-1 and PYY

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The right route depends on dosing precision, patient preference, absorption, lifestyle, and the specific hormone profile being treated