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Beyond its powerful weight-loss potential, it directly targets critical metabolic pathways linked to aging, cognitive decline, and cardiovascular disease

The Endocrine Society's 2016 position statement states that "custom-compounded bioidentical hormones are not FDA approved, and their safety and efficacy have not been evaluated in clinical trials." [7] FDA-approved estradiol and progesterone products, such as Estrace (estradiol 0.01% cream) and Prometrium (micronized progesterone 100 mg and 200 mg capsules), have undergone the full new drug application process

In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down