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Overall, GLP-1RAs may become a useful component of integrated obesity-directed KOA care, but they should be regarded as part of a proposed framework rather than as validated disease-modifying therapy

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Benefits of GLP-1 and related therapies When prescribed and monitored by a doctor, these medicines may help patients achieve: Significant weight loss Improved blood-sugar control Reduced cardiovascular risk Lower blood pressure in some patients Improved metabolic health GLP-1 receptor agonists are already widely used for type 2 diabetes and weight management, and ongoing research suggests they may have benefits beyond these conditions