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Contraception and pregnancy Women of childbearing potential participating in retatrutide trials should use effective contraception throughout

Some supplements that increase GLP-1 include compounds like berberine, prebiotic fibers such as inulin, and polyphenol-rich extracts like green tea

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Downstream signaling from hypothalamic AgRP/NPY/GABA-secreting neurons is considered redundant, meaning that selective stimulation of individual downstream projection areas is sufficient to suppress appetite