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This expression was evident in ARC, PVN, periaqueductal gray (PAG), AP (area postrema), LPB, and IML of spinal cords, but not in the hippocampus, cortex, basal ganglia, suggesting that GLP-1RAs may be activating the CNS via multiple neuroendocrine pathways

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Our chosen targets for HbA1c and weight loss are clinically relevant, associated with reduced risk of diabetes-related complications and in line with current NICE guidance [14] and our previous cost of control analyses [27]

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