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Data in panel a h comprise n = 8 mice each group

Both endogenous GIP (52) and GLP-1 (53) have very short half-lives, measured in minutes, resulting in only a small portion of these active hormones reaching the systemic circulation

Research suggests effective maintenance doses may include: 4 mg weekly 8 mg weekly 12 mg weekly Clinical trials have demonstrated dose-dependent weight loss, meaning higher doses tend to produce greater results but also carry higher risk of side effects

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