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Clinical studies so far suggest acceptable safety profiles for many regenerative therapies, but long-term data are still developing

It is unknown whether symptoms in identified patients are merely a coincidence

3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019