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8 Functions of GSH in redox buffering, detoxification, and drug resistance Glutathione (GSH) is the principal intracellular redox buffer that preserves cellular homeostasis through detoxification of ROS and regeneration of antioxidant capability via GR-catalyzed recycling of its oxidized form (GSSG)

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The intracellular proteins could reflect transfer from tumor cells to immune cells through extracellular vesicles, mitochondriaplasma membrane interactions 39 or tunneling nanotubes 40 or they could be artifacts from nonspecific binding due to our use of the monoculture (rather than coculture) no-LaccID negative control for data filtering (Fig