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The study reported that participants "regained two-thirds of their prior weight loss." A meaningful share of the loss is muscle: across body-composition studies, roughly a quarter of the weight lost is lean mass (muscle), with the rest fat (Karakasis and colleagues, network meta-analysis, Metabolism , 2024), and the honest range landing between about 15% and 40% (Hierholzer and colleagues, review, 2026)

J Biomed Sci 31 , 102 (2024)

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In particular, tell your provider if you have a past history of: Type 1 or type 2 diabetes Thyroid cancer Pancreatitis Kidney disease Diabetic retinopathy Tell your provider if you are pregnant, planning to become pregnant, or breastfeeding