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[103] Due to safety concerns, including reports of hepatotoxicity and limitations in clinical evidence, the Committee on Herbal Medicinal Products (HMPC) concluded in 2017 that the benefit-risk balance for the oral use of kava in the treatment of anxiety disorders is unfavorable, and therefore a European Union herbal monograph could not be established

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doi: 10.1002/eji.1830210804 154 McTigueMAWilliamsDRTainerJA