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The prescribing information also warns that if you take it with food or water, it lessens the efficacy of the oral tablet, and waiting longer than 30 minutes may actually increase the absorption of Rybelsus into your body

24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

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