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GLP-1 receptor agonists slow gastric emptying, meaning food and drink stay in your stomach longer

Gln depletion treatment activates FADD and caspase-8-dependent apoptosis involving pro-apoptotic TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) in tumour cells, while metabolic stress induced by glutamine deprivation leads to the downregulation of the GCN2-non-dependent FLICE-inhibitory protein (FLIP), which promotes caspase-8 activation and apoptosis [55]

257 Disruption of the colonic barrier is the most common pathological change in animal models of UC, and studies have shown that the SGLT2 inhibitor empagliflozin can significantly increase the expression of SIRT-1, suppress the levels of PI3K and AKT, and increase the levels of tight junction proteins (claudin-1 and occludin), thereby improving the integrity of the colonic barrier

Assessment of Diabetes Therapy-Related Quality of Life Scale The DTR-QoL questionnaire is a Japanese diabetes-specific HRQoL measure that contains 29 items (Table S1) to assess the influence of diabetes treatment on HRQoL across four domains [28]: burden on social activities and daily activities