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Early data suggest that engaging all three receptors may produce a more pronounced reduction in body weight than single or dual agonists, though no head-to-head outcome trials have yet been completed

What the study was about The researchers analysed electronic health records from the University of Pennsylvania Health System, comparing more than 12,000 adults prescribed GLP-1 receptor agonists with patients taking other diabetes drugs like SGLT-2 and DPP-4 inhibitors between 2019 and 2024

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