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Livadas S, Anagnostis P, Bosdou JK, et al
IGF-1 LR3 Research Applications The most established application of IGF-1 LR3 is as a growth factor supplement in serum-free mammalian cell culture, where Morris and Schmid (Biotechnology Progress, 2000) compared LongR3 against insulin in CHO lines expressing recombinant proteins, and where it is widely used as an insulin replacement at much lower concentrations
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GIP is secreted by the enteroendocrine K-cells concentrated in the proximal intestines, including the duodenum and jejunum ( via both neural and endocrine mediated factors ( Incretins act on G-protein coupled receptors on the beta cells of the pancreas, leading to a cAMP mediated pathway that ultimately results in insulin secretion ( Figure 1 )
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