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Two possible explanations for this effect are proposed: (1) reduced food intake due to an irritant effect of the treatment on the gastrointestinal tract (255, 256) or (2) a stimulant effect of TTFD on metabolism via enhanced noradrenaline secretion and thermogenesis (257)

Covariates used for the calculation of propensity score were well balanced between treated and not treated subjects after matching

Week one: Begin at 100 mcg once daily, preferably before bed

Quenching experiment The blank cuvette contained 3 ml of phosphate buffer (pH 6.5) to which aliquots (30 l) of stock solution of MBB (1mM) were repeatedly added until a total of 900 l of MBB was added