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Thereafter, throughout the 40-week extension, HbA1c was stable during DPP-4 inhibition, whereas in placebo-treated patients, HbA1c increased throughout the study period, resulting in a difference in HbA1c between the groups after 52 weeks of 1.1% (11 mmol/mol) [Figure 5

3.1 The metabolic fate of glucoraphanin and SFN Upon ingestion of cruciferous vegetables, the inert precursor glucoraphanin is hydrolyzed to its bioactive form, SFN, by the enzyme myrosinase