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Research gaps and future directions for SGLT2 inhibitors and GLP-1 receptor agonists in diabetic kidney disease SGLT2, sodium-glucose cotransporter 2

Congruently, gene expression analysis of IECs relative to respective WT controls showed elevated glucose transporter 2 ( Glut2 ) and glycolytic enzyme hexokinase 2 ( Hk2 ) expression in the jejunum of the male Tmprss2 / mice (Figure 5K), whereas female Tmprss2 / mice showed increased Glut2 expression in the duodenum (Figure 5L)

As in the PWA model, the improvement caused by GLP1/E therapy in PNA mice in terms of body weight, fat mass, food intake, and insulin sensitivity largely exceeded that of GLP1 or E monotherapies (Fig

(2025) Figure 2: Created in BioRender