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While very low sodium diets (e.g., 0.5 g/day) have been shown to accelerate ascites resolution [49], long-term adherence to such restrictive regimens is difficult and may lead to serious nutritional compromise

This has led to a dramatic increase in their use, and has stimulated the development of numerous pipeline drugs, both oral and injectable, some of which target multiple receptors, not just that for GLP-1s, said Houldsworth