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Being mindful of these risks allows you to anticipate and manage them effectively

They stated: "The 2-D method can be used for any breed, but direct extrapolation of our normal values should not be made to other breeds, because the heart has a slightly different appearance in various breeds reflecting variability in size, shape, and position within the thorax." The 2002 study's authors also were careful to exclude any findings comparing LA/Ao ratios of dogs with and without enlarged hearts

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In the laboratory study Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo (Chen and colleagues, Proceedings of the National Academy of Sciences, 2007), pharmacologic ascorbate acted as a prodrug that formed hydrogen peroxide in the extracellular space but not in blooda route-dependent effect that oral dosing did not reproduce