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Section 4135(a) and (b) of the CAA, 2023, titled Access to Non-Opioid Treatments for Pain Relief, amended section 1833(t)(16) and section 1833(i) of the Social Security Act, respectively, to provide for temporary additional payments for non-opioid treatments for pain relief (as that term is defined in section 1833(t)(16)(G)(i) of the Act)

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Data from the dosing conditions trial (NCT01572753) [15] confirmed the above model-derived conclusions regarding bioavailability: with repeated dosing, the exposure variability was reduced, and the 90% exposure range reduced from approximately 20-fold after the first dose to around five-fold after the tenth dose (Fig

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