Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype
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Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models
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