drugs that deplete glutathione Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms Glutathione Depletion and Stalwart Anticancer

Diacetyl-bis(4-methyl-3-thiosemicarbazonato) copperII (CuII(atsm)), an anti-ferroptotic compound that inhibits lipid radical propagation similarly to liproxstatin-1, rather than preventing iron oxidation, and is able to cross the BBB, has shown promising results in phase I PD clinical trials by improving disease severity (211)

The medical team can adjust infusion rates and concentrations based on patient response, which helps minimize the potential for adverse effects

Available online: 51.Lien E., Lyssiotis C.A., Juvekar A., Hu H., Asara J.M., Cantley L.C., Toker A

doi: 10.1016/j.ijid.2020.03.017 300 YuanS.JiangS.-C.ZhangZ.-W.FuY.-F.HuJ.LiZ.-L