tirzepatide adverse effects Comparative safety and side of semaglutide and tirzepatide: Implications for clinical decision-making in obesity management AMRA Used in Tirzepatide Analyses

A recent MedPage Today feature shed light on an unsettling trend among users of GLP-1 medications, dubbed Ozempic mouth or Ozempic teeth. These users are experiencing symptoms ranging from dry mouth and persistent bad breath to gum sensitivity and enamel erosion

The involvement of DPP-4 in metabolism of endogenous SDF-1 is compatible with the finding that the truncated metabolite, SDF-1 3-67, was present in wild-type mice, but not in animals lacking DPP-4 (62), with this observation being extended in subsequent studies in mice and Rhesus monkeys (63) and in patients with T2DM (64) showing that levels of SDF-1 3-67 were reduced while those of the intact 1-67 form increased concomitantly when DPP-4 activity was inhibited

Cells 11:190

These are not marginal changes