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The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage

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Free Radical Biol Med 46:154162 [DOI] [PMC free article] [PubMed] [Google Scholar] Reed M, Meszaros K, Entes L, Claypool M, Pinkett J, Brignetti D, Luo J, Khandwala A, Reaven G (1999) Effects of maso-procol on carbohydrate and lipid metabolism in a rat modelof type II diabetes

The peptide supports the Muller cells, which regulate retinal function and protect the eye against pathogens [11]