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A small clinical trial reported meaningful density and thickness increases after six months of scalp injections

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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

Considering the framework of the Sustainable Development Agenda and the need for equitable, inclusive and resilient communities, the paper tries to envisage the future of peri-urban spaces, that is to say the visions, tactics and models that lead to the economic, social and environmental sustainability of these areas