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Other research, including a 2025 study published in Nature Medicine , has explored potential links between GLP-1 use and lower risks of conditions such as substance use disorders and dementia

Obesity is common in people with HS, and some studies suggest that losing weight might improve HS symptoms

In a pooled metanalysis of major placebo-controlled trials, Sattar et al found a 12% reduction in all-cause mortality and 14% relative risk reduction in 3-point MACE

Room temperature exposure Most compounded tirzepatide can tolerate room temperature (up to 77 to 86 degrees Fahrenheit or 25 to 30 degrees Celsius) for limited periods, typically up to 21 days according to many pharmacy guidelines