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Efficacy Across Diuretic Subgroups Regarding the first primary endpoint of change in heart failure-related symptoms and physical limitations from baseline to 52 weeks, semaglutide improved KCCQ-CSS in all diuretic subgroups, but the magnitude of improvement was greater in patients receiving loop diuretics compared to those not on loop diuretics, with an adjusted mean difference vs

The American Diabetes Association's Standards of Care recognize GLP-1 receptor agonists with proven cardiovascular benefit as preferred agents for patients with established atherosclerotic cardiovascular disease or indicators of high cardiovascular risk

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