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Although most studies included several medications, current guidelines recommend selecting GLP1-RAs and SGLT2is on the basis of their clinically proven benefits rather than class alone

Overall, the type and severity of adverse reactions in adolescents and children aged 10 years and above were comparable to those observed in the adult population

Patients with IBS-D (diarrhoea-predominant) may be particularly concerned about GLP-1-induced diarrhoea, whilst those with IBS-C (constipation-predominant) might experience either improvement or worsening depending on individual response

That said, individual responses vary, and monitoring results helps ensure the combination works as intended