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The rationale for combining these two peptides is mechanistic complementarity

In: GantaitSMajumderJSharangiAB, editors

There is also evidence for mechanisms involving a reduction of neuroinflammation, an increase in synaptic functioning, as well as the restoration of brain pathways of insulin signaling that may lead to improved memory formation and therefore a positive effect in Alzheimers disease and Parkinsons disease, note the authors

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference