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Unintended muscle loss, which often accompanies rapid weight loss, is another common concernand another reason why protein products are flying off shelves

(B) Semaglutide, as a GLP-1 analog, can directly act on fat cells, increase the expression of thermogenic genes for browning phenotype maintenance, improve the expression of uncoupling protein 1 (UCP1), mitochondrial biosynthesis, and thermogenic marker, or promote fatty browning through nitric oxide synthase (NOS), neuropeptides (NPs), sirtuin 1 (STRT1), signal transducer and activator of transcription 3 (STAT3), and bone morphogenetic protein 4 (BMP4) signaling

20 The researchers didnt find an increased risk for proliferative diabetic retinopathy or for diabetic retinopathy/diabetic macular edema requiring treatment with semaglutide compared to the other GLP-1 RAs or to the non-GLP-1 RA antihyperglycemic medications