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PMID 37952131 DOI Aroda VR, Rosenstock J, Terauchi Y, et al

While four major defense systems, including the GPX4-GSH axis, FSP1-CoQ 10 pathway, DHODH-CoQ 10 system, and GCH1-BH4 pathway, are known to regulate redox homeostasis and lipid peroxidation, their inhibition elicits heterogeneous responses across PDAC models

The deficiency becomes one possibility among a long list, and it is not always the first to be investigated

Iacobellis et al