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doi: 10.1016/j.pcad.2024.12.010

Speculation regarding cause has invoked developmental factors or hormonal changes such as occur in adolescence and pregnancy

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On the other hand, the Danish Steno-2 study found that while intensive multifactorial intervention (targeting glucose, blood pressure, lipids and other risk factors) dramatically reduced cardiovascular events and mortality by approximately 50%, it showed no significant reduction in DPN (HR 1.12), suggesting that neuropathy may be more resistant to multifactorial interventions compared with other diabetic complications [62]