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Salt and Crystal Engineering The clinical candidate uses the optimized TRIS salt Form A monohydrate (WO2024217553A1, CAS: 3059756-05-4)

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In terms of glycemic control, these agents affect glucose metabolism through distinct pathways: GLP-1RAs enhance glycemic control by stimulating glucose-dependent insulin secretion, while SGLT2is lower blood glucose levels by inhibiting glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion